[Verse One: Oxidate it or Love it] Yeah – let's eat a snack. Uh huh In high school I was confused by the oxidation of food It seemed too complex, glycoly- had me confused But it's a simple concept, so now I'm in the mood for Learnin' how I'm burnin' glucose as a food source I wanna live good so my cells take energy From the bonds in the sugar put ‘em into ATP Takes ten enzymes and it takes ten steps Wind up with two pyruvates, yeah, they still got energy left So mitochondria can take ‘em to burn It down to acetyl CoA so Kreb's gon' turn So the energy you get from eating them blue berries Is ferried to where high-energy electrons are carried [Chorus One: Oxidate it or Love it] Hate it or love it glycolysis gon' chop Glucose down to two three-C blocks Go head study me. I make ATP And I'ma be on your test, so you should get to know me And if you've got enough oxygen in stock Kreb's gon' cycle, homey, until your heart stops Go ahead study me. I help make ATP By making NADH, so you should get to know me [Verse Two Teaser: Oxidate ir or Love it] NADH Dehydro! Inner-Membrane of the Mitochon Using NADH from Kreb's to pump protons Thanks to electrons, which we're transporting So important that we got to switch it to the next song [Chorus Two: “Electron to the Next One”] Got so many ways to pump protons…. choose one Now let ‘em flow. And watch your ATP supply grow Electron to the next one, on to the next one Electron to the next one, on to the next one Electron to the next one, on to the next one Hold up, freeze. Somebody synthesize some ATPs! [Verse Two: “Electron to the Next One”] Oxy Phos is pretty complex. Students say how come? If it wasn't so many steps – inefficient outcome If the energy from the food that you eat Was burned in one big step, then you'd lose more as heat So when those e minuses move down the chain They make protons move across the membrane And when the pro- flow gets the synthase arumbling To make ATP - chemiosmotic coupling But as electrons get pa**ed along, see To help do their work, they lose a little moxy So by the end, you gonna need an oxy To remove the e- and keep it rolling like Yahtzee Kreb's is making CO2, and oxy's oxidating Why do you think they call it cellular respiration? Burning our food to make ATP stacks, son Oxygen present? Electron to the next one Lollipops and tangerines Somebody synthesize some ATPs [Verse Three: “Oxidate it or Love it”] So all you kids thinking, “What's the point of all these Crazy steps, what a mess, makin' ATPs? Why you gotta do from glu- to pyru- from Co-As to synthase?” Shoot, why do you think we need to breath? Well, adenosine triphosphate's beauty - It ain't hard to tell - helps the cell do its duty Even Judy could judge that crucial to me To pump sodium out or keep myosin moving Which is to say that it's fuel for your brain Or your muscles in a tussle, insane So when you think, jerk, run, ball, take a test, or drop new flows Remember how you make ATP out of glucose [Chorus 3: “Oxidate it or Love it”] Hate it or love it glycolysis gonna chop Glucose down to two three-C blocks Go ahead study me I make ATP And if you eat a burrito then you can get to know me And if you got enough oxygen in stock Mitochondria will do oxy phos Go ahead study me, I make ATP I make a helluva lot, so you should get to know me