What happened to Adam and Eve when they sinned? Instead of being holy and happy, they became sinful and miserable. Instead of being holy and happy, they became sinful and miserable. Knowing good and evil, Genesis 3:22, good and evil. What happened to Adam and Eve when they sinned? Instead of being holy and happy, they became sinful and miserable. Knowing good and evil, Genesis 3:22, good and evil.